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mild cognitive disorder

MedGen UID:
220863
Concept ID:
C1270972
Mental or Behavioral Dysfunction
Synonyms: Cognitive Impairment, Mild; Cognitive Impairments, Mild; Impairment, Mild Cognitive; Impairments, Mild Cognitive; Mild Cognitive Impairment; Mild Cognitive Impairments
SNOMED CT: Mild cognitive disorder (386805003); Mild cognitive impairment (386805003)

Definition

Some forgetfulness can be a normal part of aging. However, some people have more memory problems than other people their age. This condition is called mild cognitive impairment, or MCI. People with MCI can take care of themselves and do their normal activities.CHAR(13) MCI memory problems may include:CHAR(13) -Losing things often. CHAR(13) -Forgetting to go to events and appointments. CHAR(13) -Having more trouble coming up with words than other people of the same age. CHAR(13) Memory problems can also have other causes, including certain medicines and diseases that affect the blood vessels that supply the brain. Some of the problems brought on by these conditions can be managed or reversed.CHAR(13) Your health care provider can do thinking, memory, and language tests to see if you have MCI. You may also need to see a specialist for more tests. Because MCI may be an early sign of Alzheimer''s disease, it''s really important to see your health care provider every 6 to 12 months.CHAR(13) At this time, there is no proven drug treatment for MCI. Your health care provider can check to see if you have any changes in your memory or thinking skills over time.CHAR(13) NIH: National Institute on AgingCHAR(13) [from MedlinePlus]

Professional guidelines

PubMed

Christensen H, Batterham PJ, Mackinnon AJ, Jorm AF, Mack HA, Mather KA, Anstey KJ, Sachdev PS, Easteal S
BMC Geriatr 2008 Jul 14;8:14. doi: 10.1186/1471-2318-8-14. PMID: 18620605Free PMC Article
Weyerer S, Eifflaender-Gorfer S, Köhler L, Jessen F, Maier W, Fuchs A, Pentzek M, Kaduszkiewicz H, Bachmann C, Angermeyer MC, Luppa M, Wiese B, Mösch E, Bickel H; German AgeCoDe Study group (German Study on Ageing, Cognition and Dementia in Primary Care Patients)
J Affect Disord 2008 Dec;111(2-3):153-63. Epub 2008 Mar 26 doi: 10.1016/j.jad.2008.02.008. PMID: 18372049

Recent clinical studies

Etiology

Shi R, Yu S, Larbi A, Pin Ng T, Lu Y
Brain Behav Immun 2024 Oct;121:155-164. Epub 2024 Jul 21 doi: 10.1016/j.bbi.2024.07.026. PMID: 39043350
Julkunen V, Schwarz C, Kalapudas J, Hallikainen M, Piironen AK, Mannermaa A, Kujala H, Laitinen T, Kosma VM, Paajanen TI, Kälviäinen R, Hiltunen M, Herukka SK, Kärkkäinen S, Kokkola T, Urjansson M; FinnGen, Perola M, Palotie A, Vuoksimaa E, Runz H
Sci Rep 2023 Aug 3;13(1):12641. doi: 10.1038/s41598-023-39835-7. PMID: 37537264Free PMC Article
Đapić B, Schernhammer E, Haslacher H, Stögmann E, Lehrner J
J Neuroendocrinol 2022 Apr;34(4):e13107. Epub 2022 Feb 25 doi: 10.1111/jne.13107. PMID: 35213057Free PMC Article
Liew TM
Alzheimers Res Ther 2020 Sep 11;12(1):107. doi: 10.1186/s13195-020-00673-8. PMID: 32917264Free PMC Article
Béjot Y, Bailly H, Durier J, Giroud M
Presse Med 2016 Dec;45(12 Pt 2):e391-e398. Epub 2016 Nov 2 doi: 10.1016/j.lpm.2016.10.003. PMID: 27816343

Diagnosis

Julkunen V, Schwarz C, Kalapudas J, Hallikainen M, Piironen AK, Mannermaa A, Kujala H, Laitinen T, Kosma VM, Paajanen TI, Kälviäinen R, Hiltunen M, Herukka SK, Kärkkäinen S, Kokkola T, Urjansson M; FinnGen, Perola M, Palotie A, Vuoksimaa E, Runz H
Sci Rep 2023 Aug 3;13(1):12641. doi: 10.1038/s41598-023-39835-7. PMID: 37537264Free PMC Article
Liew TM
Alzheimers Res Ther 2020 Sep 11;12(1):107. doi: 10.1186/s13195-020-00673-8. PMID: 32917264Free PMC Article
Gomersall T, Smith SK, Blewett C, Astell A
Br J Health Psychol 2017 Nov;22(4):786-804. Epub 2017 Jun 19 doi: 10.1111/bjhp.12255. PMID: 28628736
Titlic M, Bradic-Hammoud M, Miric L, Punda A
Bratisl Lek Listy 2009;110(9):576-9. PMID: 19827343
Reischies FM, Hellweg R
Compr Psychiatry 2000 Mar-Apr;41(2 Suppl 1):66-75. doi: 10.1016/s0010-440x(00)80011-5. PMID: 10746907

Therapy

Hopkins J, McVeigh J, Hill K, Ellis KA, Jacques A, Burton E
Aust Occup Ther J 2024 Aug;71(4):527-539. Epub 2024 Apr 14 doi: 10.1111/1440-1630.12944. PMID: 38616178
Julkunen V, Schwarz C, Kalapudas J, Hallikainen M, Piironen AK, Mannermaa A, Kujala H, Laitinen T, Kosma VM, Paajanen TI, Kälviäinen R, Hiltunen M, Herukka SK, Kärkkäinen S, Kokkola T, Urjansson M; FinnGen, Perola M, Palotie A, Vuoksimaa E, Runz H
Sci Rep 2023 Aug 3;13(1):12641. doi: 10.1038/s41598-023-39835-7. PMID: 37537264Free PMC Article
Hopkins J, Hill K, Jacques A, Burton E
Clin Rehabil 2023 Feb;37(2):215-243. Epub 2022 Oct 3 doi: 10.1177/02692155221129832. PMID: 36189497
Rajji TK, Bowie CR, Herrmann N, Pollock BG, Bikson M, Blumberger DM, Butters MA, Daskalakis ZJ, Fischer CE, Flint AJ, Golas AC, Graff-Guerrero A, Kumar S, Lourenco L, Mah L, Ovaysikia S, Thorpe KE, Voineskos AN, Mulsant BH; PACt-MD Study Group
J Alzheimers Dis 2020;76(2):733-751. doi: 10.3233/JAD-200141. PMID: 32568198
Cherbuin N, Anstey KJ
Am J Geriatr Psychiatry 2012 Jul;20(7):635-9. doi: 10.1097/JGP.0b013e31823032a9. PMID: 21937919

Prognosis

Shi R, Yu S, Larbi A, Pin Ng T, Lu Y
Brain Behav Immun 2024 Oct;121:155-164. Epub 2024 Jul 21 doi: 10.1016/j.bbi.2024.07.026. PMID: 39043350
Liew TM
Alzheimers Res Ther 2020 Sep 11;12(1):107. doi: 10.1186/s13195-020-00673-8. PMID: 32917264Free PMC Article
Gomersall T, Smith SK, Blewett C, Astell A
Br J Health Psychol 2017 Nov;22(4):786-804. Epub 2017 Jun 19 doi: 10.1111/bjhp.12255. PMID: 28628736
Béjot Y, Bailly H, Durier J, Giroud M
Presse Med 2016 Dec;45(12 Pt 2):e391-e398. Epub 2016 Nov 2 doi: 10.1016/j.lpm.2016.10.003. PMID: 27816343
Reischies FM, Hellweg R
Compr Psychiatry 2000 Mar-Apr;41(2 Suppl 1):66-75. doi: 10.1016/s0010-440x(00)80011-5. PMID: 10746907

Clinical prediction guides

Shi R, Yu S, Larbi A, Pin Ng T, Lu Y
Brain Behav Immun 2024 Oct;121:155-164. Epub 2024 Jul 21 doi: 10.1016/j.bbi.2024.07.026. PMID: 39043350
Liew TM
Alzheimers Res Ther 2020 Sep 11;12(1):107. doi: 10.1186/s13195-020-00673-8. PMID: 32917264Free PMC Article
Béjot Y, Bailly H, Durier J, Giroud M
Presse Med 2016 Dec;45(12 Pt 2):e391-e398. Epub 2016 Nov 2 doi: 10.1016/j.lpm.2016.10.003. PMID: 27816343
Lucza T, Karádi K, Kállai J, Weintraut R, Janszky J, Makkos A, Komoly S, Kovács N
Behav Neurol 2015;2015:983606. Epub 2015 May 19 doi: 10.1155/2015/983606. PMID: 26078489Free PMC Article
Reischies FM, Hellweg R
Compr Psychiatry 2000 Mar-Apr;41(2 Suppl 1):66-75. doi: 10.1016/s0010-440x(00)80011-5. PMID: 10746907

Recent systematic reviews

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